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A report from the "Quantitative challenges in the post-genomic sequence era" workshop and symposium, San Diego, January 11-15, 2000
A report on work presented at the 39th Annual Meeting of the American Society for Cell Biology, Washington DC, December 11-15, 1999
A report on work with small-molecule inhibitors of cellular processes presented at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
A report from the minisymposium on regulated secretion at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
A report on work presented at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
Launched in September 1998, dbSNP is the central repository for data on single-nucleotide polymorphisms (SNPs), the most common form of sequence variation in human populations.
Given the variety of codon usage by different organisms and organelles, this centralized codon-usage resource is invaluable.
The purpose of CODEHOP is to help in the design of degenerate PCR primers from protein sequence.
For those interested in genome-wide or more restricted comparisons of proteins across species, the Clusters of Orthologous Groups (COGs) website provides the kind of information many of us want.
The sequence tag alignment and consensus knowledgebase (STACK) is an international collaborative project on EST clustering.
The Protomap program classifies proteins into clusters according to sequence similarity.
Finding the relevant database is not always easy, and for some years Nucleic Acids Research has dedicated its first issue of the year to information about the most important existing databases.
The availability of complete genomic sequences of Saccharomyces cerevisiae has catalyzed a cultural change in the practice of yeast biology, providing opportunities to develop high throughput techniques to define...
For those working on the actin cytoskeleton, a major theme of the 39th annual meeting of the American Society for Cell Biology [
The key molecules involved in regulating the assembly and function of the mitotic spindle are shared by evolutionarily divergent species. Studies in different model systems are leading to convergent conclusion...
GeneCalling, a new expression profiling technique, has been used to elucidate regulatory gene networks in plants.
A sensitive coexpression algorithm detects new genes associated with markers of prostate cancer.
A novel method for the synthesis of 5'-attached oligonucleotides that eliminates truncated sequences may improve microarray construction.
Serial analysis of gene expression (SAGE) has been used to analyze the complete human 'transcriptome' - the number, identity and level of expression of genes in humans.
Members of the Arabidopsis Genome Initiative, including the European Union Arabidopsis Genome Sequencing Consortium and The Cold Spring Harbor, Washington University in St Louis and PE Biosystems Arabidopsis Sequ...
Members of the Arabidopsis Genome Initiative, primarily from The Institute for Genomic Research, have completed sequencing one of the first two plant chromosomes.
A maize transposable element has been used to generate a tool for identifying gene function in Arabidopsis thaliana.
Mouse chromosomes carrying deletions have been produced using a combination of targeted and random integration of selectable markers followed by specific excision by a recombinase.
PCR screening five collections of mutagenized Arabidopsis lines to find those that have T-DNA or transposon insertions in 73 members of the R2R3 MYB gene family has identified 47 insertions into 36 genes.
A new noninvasive technique has been developed that successfully measures calcium dynamics in single Arabidopsis guard cells.
Many protein-protein interactions are identified at once using high-throughput yeast two-hybrid screens.
The design and testing of a neural network to predict phosphorylation sites on proteins is described.
The entire human major histocompatibility complex (MHC), a genomic region critical for immune defense, has been sequenced.
The crystal structure of human SRP54M from the signal recognition particle (SRP) reveals a homodimer interaction, which may be a model for the way signal sequences on nascent proteins recognize and activate th...
Systems analysis of the complete genome sequence combined with biochemical information on metabolic pathways has been used to define and elucidate the relationship between genotype and phenotype for Haemophilus i...
Correlation-based clustering of plant expressed sequence tags allows conclusions to be drawn about the relationship between genes based on their expression patterns in different tissues.
Differences in responses to bacterial surface lipopolysaccharides (LPSs) are apparent between and within mammalian species. It has been shown in mice that resistance to LPS is caused by defects in the Toll-lik...
The formin family of proteins has been implicated in signaling pathways of cellular morphogenesis in both animals and fungi; in the latter case, at least, they participate in communication between the actin cy...
The use of cDNA microarrays for the study and mapping of gene amplifications and deletions on a whole-genome scale provides a comparison of DNA copy numbers in normal and tumor cells at unprecedented resolution.
Several programs to predict sequence and structural features of a protein can be run simultaneously on the PredictProtein server.
The NetGene2 server uses a neural network combined with a rule-based system to predict intron splice sites in Arabidopsis thaliana, Caenorhabditis elegansand humans.
Data are collected from Nature, Science, Cell, and Nature Cell Biologyto form a database and resource for the signaling pathways of human cells.
The signaling pathway database is an integrated database that links signal transduction systems to genetic information.
Publicly available nucleotide sequences, along with their associated annotations are available here.
This online version of a US Department of Energy publication provides detailed background information about the human genome project.
This site has a collection of features dealing with different areas of genetic research, and is an interesting and useful piece of 'popular science'.
Developmental biology, primarily work with the embryos of Xenopus species X. laevis and X. tropicalis, is the focus of this site.
A comprehensive repertoire of tools available to attack fundamental biological problems is presented here.
This comprehensive online biology reference book consists of lists of terms covering an extensive range of biological topics, and is aimed primarily at graduate students.
Providing a central scientific forum, run by scientists for scientists is the aim of this new and developing site, which shows a lot of potential.
SYFPEITHI, a database of interactions between proteins of the major histocompatibility complex (MHC) and antigenic peptides, contains information on MHC-associated peptide sequences, anchor positions, MHC mole...
Bioinformatic analysis has been used to identify gene-fusion events in complete genomes and thus infer protein interactions on the basis of sequence analysis alone.
The isolation of a putative receptor protein for rhizobial nod factors that is located on the surface of legume roots and also has nucleotide hydrolytic properties is described.
Can the selection by aminoacyl-tRNA synthetases for the correct tRNA substrate happen during binding? The results of equilibrium experiments suggest that it can.
YopJ, a virulence factor of Yersinia pseudotuberculosis, can bind to several key intracellular signaling proteins, members of the MAPKK family, preventing their activation and protecting the pathogen from host de...
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