Fig. 8

Modules of transcription factors in the genetic regulatory network (GRN) of 3 FTx. GRN inferred for the cytotoxic and neurotoxic 3 FTx using the toxin cells. Neurotoxins, cytotoxins, shared TFs, and neurotoxin-specific TFs are colored in red, blue, purple, and orange, respectively. The size of circles represents the out-degree of genes in the GRN. The orange edges indicate which neurotoxin-specific TF is binding to the neurotoxic 3 FTx. The magenta and dark purple edges indicate which shared TF is binding to neurotoxins or cytotoxins, respectively. The gray edges indicate the protein-protein interactions between TFs retrieved from the STRING database. On the right, the degree (total number of connections of each node), in-degree (number of incoming connections), out-degree (number of outgoing connections), and betweenness (number of times a node is the shortest path between other nodes) centrality measures obtained for each gene in the GRN showing relevant TFs controlling the 3 FTx expression profile observed