Fig. 4
From: The gene regulatory mechanisms shaping the heterogeneity of venom production in the Cape coral snake
Transcription factors (TFs) identified as candidates to regulate the toxin gene expression using the toxin cells. Rows correspond to the TFs homologous to profiles at JASPAR in toxin modules and columns correspond to toxin genes in the toxin modules. Circles indicate transcription factor binding sites (TFBSs) in the promoter of the toxin gene. The size corresponds to the number of predicted TFBSs in a given promoter, in which larger circles represent more bound sites. The color corresponds to the network adjacency weights calculated using GENIE3, in which lighter colors represent higher weights. The columns on the far right show the family and function for each TF, indicating whether they were previously implicated in toxin production, directly interacting to the ERK/MAPK pathway, and/or interacting into the UPR pathway (purple squares)