Fig. 8

Working model of ZAR1 functions in orchestrating mRNA polyadenylation during oocyte development A Maternal transcriptome are deadenylation, rather than degradation, during meiosis. Genes whose transcripts decay after GVBD are termed O-decay genes, which primarily function in quiescent GV stage oocytes. B ZAR1 binds to the 3′ UTR of mRNAs to regulate their stability and also influences the polyadenylation of other proteins. C ZAR1 interacts with other proteins that regulate mRNA stability and polyadenylation to the homeostasis of the maternal transcriptome in oocytes. Red line: polyadenylated tails of mRNAs. Black wave: mRNA body. Dark green wave: mRNA bodies of O-decay genes. Pink star: Translating mRNAs. Light green line: 5′ UTR of mRNAs. Teal line: 3′ UTR of mRNAs. Red rectangle: ZAR1 protein