Fig. 6
From: PRESCOTT: a population aware, epistatic, and structural model accurately predicts missense effects
ESCOTT highlights functionally relevant regions of proteins. A Spearman correlation coefficients between positional averages of the 28 single point mutation DMS matrices and predicted matrices in ProteinGym. Black squares correspond to the values reported in Fig. 3 for ESCOTT. B Averaged scores from experiments, ESCOTT and AlphaMissense are projected onto the human Thiopurine methyltransferase (TPMT_HUMAN in A) enzyme. A viridis color scale was used for low (blue) versus high (yellow) average scores projected onto the protein structure. Gray residues (in positions 95, 96, 117, 172) are associated to absence of experimental data. Protein visualizations were realized with PyMOL [36]