Fig. 3

Comparison of ESCOTT, EVE (ensemble), ESM1b and AlphaMissense on 32 DMS experiments for human proteins. A ESCOTT (black squares), EVE (ensemble, green circle), ESM1b (blue diamond) and AlphaMissense (brown stars). Dashed lines indicate average Spearman correlation coefficients of the predictive methods with experimental data from the 32 human DMS experiments in the ProteinGym dataset: solid black line for ESCOTT, dashed dotted brown line for AlphaMissense, dashed green line for EVE (ensemble), dotted blue line for ESM1b. B Comparison of ESCOTT (black) with existing methods. The list of methods includes EVE (ensemble), AlphaMissense, iGEMME (red), GEMME (purple), and ESM1b. Data for all other methods was obtained from https://www.proteingym.org/substitutions-dms-level, except for AlphaMissense and PoET (ensemble) which are reported in [19] and [33], respectively