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Fig. 3 | Genome Biology

Fig. 3

From: Variant effect predictor correlation with functional assays is reflective of clinical classification performance

Fig. 3

The top 30 out of 83 tested VEPs in terms of clinical variant classification performance. VEPs are ranked according to their average win rate against all other VEPs in pairwise AUROC comparisons across all human proteins with at least 10 pathogenic and 10 putatively benign missense variants. The number of proteins that met this condition for each predictor is indicated on the right of the plot. Some VEPs from the DMS benchmark could not be included here because predictions were not available for enough genes. Error bars represent the standard error across all comparisons with other VEPs. The full ranking of all VEPs and all pairwise win rates are available in Additional file 2: Table S8

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Genome Biology

ISSN: 1474-760X

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