Fig. 6

Applying RobusTAD to Hi-C data for GM12878 cells reveals TAD groups. a A two-dimensional UMAP projection of TADs based on the occupancy of transcription factors at domain boundaries. b Occupancy of transcription factors in each group of TADs. c two-dimensional distributions in the UMAP projected space of TADs associated with different features. d Occupancy of different pairs of directional CTCF binding sites at domain boundaries. E-P links are domains supported by POLR2 A ChiA-PET data. e Proportion of annotated TADs with different regulatory element combinations at domain boundaries. Enrichment of ATAC-seq peaks (f) and insulation scores (g) at domain boundaries for each TAD group. h Rescaled pileup plots over TAD predictions for each TAD group