Fig. 2
From: RobusTAD: reference panel based annotation of nested topologically associating domains
Comparison of RobusTAD, and 14 other TAD callers on a GM12878 Hi-C data set of 250M valid read pairs. a Number of TADs predicted by different tools, and proportion of predicted TAD boundary pairs that are supported by CTCF ChIA-PET data. b Size distribution of predicted TADs. c U-MAP analysis performed on the Pearson’s correlation matrix of the matrix of pairwise MoC between TADs identified by all callers. Comparison of the quality of TADs predicted by different tools using RobusTAD’s TAD score (d), and TAD mean interaction frequency (observed/expected) (e). f Fold change of structural protein peak signals at TAD boundaries for CTCF, RAD21, and SMC3. Number of left (g) and right (h) boundaries that contain at least one CTCF ChIP-seq peak. i Fraction of TADs with significant log10 ratio between H3 K27 me3 and H3 K36 me3. Note: Panels c, f–i are generated with benchmarking code created by Zufferey et al. [24]