Fig. 4
From: Bayesian multi-study non-negative matrix factorization for mutational signatures
Results from a simulation with covariates, using 10 simulated datasets. A Under the discovery-only model, posterior inclusion probabilities for the two covariates (gender and age) in a study with ground-truth non-null effects in two signatures and a ground-truth null effect in the other signature. B Under the discovery-only model, estimated associations with gender and age for the two signatures with non-null effects. The true associations are indicated by the dark blue and dark red lines, and the lighter opacity lines indicate estimated associations from each simulation run. C Under the recovery-discovery model, posterior inclusion probabilities. D Under the recovery-discovery model, estimated associations