Fig. 2

Simulation results in the setting without covariates. A Sensitivity and precision for the three-study simulation, comparing our discovery-only and recovery-discovery approaches to existing methods. Points represent median sensitivity and precision for each approach across 10 simulated datasets; horizontal and vertical error bars indicate the 10th and 90th quantile values. Here, signeR and SigProfiler refer to running those methods on each study individually, while signeR concat and SigProfiler concat refer to running those methods on all studies concatenated. B Cosine similarities in the three-study simulation for a subset of signatures that are estimated under all approaches. C Sensitivity and precision for the ten-study simulation. D Cosine similarities in the ten-study simulation for a subset of signatures that are estimated under all approaches