Fig. 5
From: Weighted 2D-kernel density estimations provide a new probabilistic measure for epigenetic age
Variation score shows significant association with mortality. A The association of epigenetic age-predictions with all-cause mortality was analyzed in the Lothian Birth Cohort of 1921 (LBC1921). Kaplan-Meier survival curves are depicted for highest and lowest 10% delta ages. Cox regression model for all donors, adjusted for chronological age and sex, showed no significant effect of delta age in mortality risk (HR = 0.9998, 95% CI (0.988, 1.012), P = 0.978). B Individual Cox regressions for all the 27 CpGs in WKDE (adjusting for age and sex) revealed 4 significantly mortality-associated CpGs in the LBC1921. The cg11436113 was also significantly associated with mortality in the Lothian Birth Cohort of 1936 (LBC1936). C Kaplan-Meier survival curves for donors with highest and lowest 10% DNAm at cg11436113 in the LBC1921. Cox regression model, adjusted for chronological age and sex, shows that increase of 1% in the DNAm of cg11436113 is associated with a 1.94% decrease in mortality risk (95% CI (0.9665, 0.9949), P = 0.0080). D Kaplan-Meier survival curves for highest and lowest 10% variation score in the LBC1921. Cox regression model, adjusted for chronological age and sex, shows that increase of 1 unit in the variation score is associated with a 9.2% decrease in mortality risk (95% CI (0.8387, 0.9872), P = 0.0160)