Fig. 3
From: Weighted 2D-kernel density estimations provide a new probabilistic measure for epigenetic age
WKDE allows to measure heterogeneity in age-associated DNAm. A Possible age (y-axis) vs. probability (x-axis) for eight random samples from the training set. The thickness of the plot represents how probable is that a sample belongs to that age. B Chronological vs. predicted age in the training set measured with WKDE. Vertical lines depict predicted age ± variation score. C Same as in panel B for validation set. D Chronological age vs. variation score. E Predicted age vs. variation score. F Delta age vs. variation score. Variation score reflects almost no correlation with delta age measured with WKDE. G Boxplot of delta age vs. sex. Delta age distributes evenly across males and females (Wilcoxon rank sum test P = 0.27). H Boxplot of variation score vs. sex. Variation score distributes evenly across males and females (Wilcoxon rank sum test P = 0.89)