Fig. 5

Cell lines with higher mitochondrial content show differential resistance and sensitivities to drugs. a Comparison of the function of the top 15 drugs with the highest association between pctMT and drug resistance (resp. drug sensitivity) and the set of tested drugs. All drugs tested on the CCLE are classified into categories according to their target. The fraction of drugs falling into each category is plotted. Significance is computed using a Fisher exact test. b,c Correlation between the pctMT of cell lines stratified by cancer type and IC50 of specific drugs for the top 15 drugs with the highest median correlation across cancer types (b) and the top 15 drugs with the lowest median correlation across cancer types (c). For each cancer type, Pearson’s correlation between pctMT and IC50 of all cell lines is computed. Significance is computed using Student’s t test. d,e Distribution of pctMT across the Kuramochi cell line’s treatment-sensitive and resistant clones, treated with Olaparib (d) and Carboplatin (e). Significance is computed using a Mann–Whitney U test. Dotted lines correspond to the median pctMT value in treatment-sensitive cells. *: \(0.01\le p<0.05\); **: \(0.001\le p<0.01\); ***: \(p<0.001\). CCLE: Cancer Cell Line Encyclopedia