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Fig. 4 | Genome Biology

Fig. 4

From: Filtering cells with high mitochondrial content depletes viable metabolically altered malignant cell populations in cancer single-cell studies

Fig. 4

Transcriptomic and metabolic characterization of malignant cells with high mitochondrial content. a Distribution of metacell scores of mitochondrial fission across malignant compartments. b Distribution of metacell scores of mitochondrial transfer across malignant compartments. Significance is computed using a Kruskall-Wallis test. c Heatmap of the dysregulation of the 72 MitoCarta metabolic pathways. The hue represents the difference in median score of the pathway between the HighMT metacells and LowMT metacells. Pathways are ordered according to median difference. d Distribution of signature scores of genes involved in xenobiotic metabolism in the seven studies. The score of CYP genes (phase I), UGT and GST genes (phase II), and ABC transporters (phase III) are compared between HighMT and LowMT metacells for each study. Significance is computed using a Mann–Whitney U test. ns: \(p>0.05\); *: \(0.01<p\le 0.05\); **: \(0.001<p\le 0.01\); ***: \(0.0001<p\le 0.001\); ****: \(p\le 0.0001\)

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Genome Biology

ISSN: 1474-760X

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