Fig. 3

Application of InSituCor to a tissue microarray of PDAC tumors. a Consensus correlation structure: gene pairs with correlations > 0.3 in ≥ 17/19 tumors. b Expression of “S100A6” module genes (S100A6, JUP, ANXA2, EZR, CEACAM6, KRT19, KRT8, TSMB10, TSMB4X, LMNA, PKM, TACSTD2, CLDN4, CRIP1, SPRINT2) in cancer cells of tumor 10B-7. c Conditional correlations of 307 gene pairs showing inter-tumor heterogeneity. Each element shows a gene pair’s conditional correlation estimate from a single tumor. Top bar color denotes the gland size characterizing each tumor. d Tumor-specific conditional correlations from a cluster of the gene pairs from c. e Expression of a module constructed from the selected cluster of gene pairs (COX1, COX2, SPINT2, S100A4, S100A6, S100A14). Cancer cells are colored by average expression of module genes; other cells are grey