Fig. 2

Biology-first use of InSituCor. a Correlation structure of 51 ligands assigned to modules. Edges show conditional correlations > 0.1, and color shows module membership. b. Involvement of each cell type in each module. c, d, e Environment expression of a modules holding chemoattractants (c), MHC2 antigen presentation genes (d), and MHC1 antigen presentation genes (e). Color scale ranges from 0 expression to the 95th percentile of the module’s expression. f Conditional correlations of 555 ligand-receptor pairs. g Spatial map of single-cell expression of the ligand-receptor pair FCER2 and CR2. h Conditional correlation network around the FCER2-CR2 ligand-receptor pair. i Expression of “B-cell migration and maturation” module in tertiary lymph nodes. j Expression of “MHC Class II antigen presentation and antibody production” module in tertiary lymph nodes