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Fig. 2 | Genome Biology

Fig. 2

From: TF Profiler: a transcription factor inference method that broadly measures transcription factor activity and identifies mechanistically distinct networks

Fig. 2

Generating and clustering of TF profiles. A Scatter plot showing the expected (x-axis) and observed (y-axis) MD-scores for all PSSMs in HOCOMOCO for embryonic stem cells [38]. Significant differences are colored with ON-UP red and ON-DOWN blue (see Methods section). The collection of ON and OFF (gray) labels is the TF profile for this experiment. B Ward clustering of TF profiles (columns) in 126 samples representing over twenty tissue types. Each sample is labeled by its tissue of origin (top, colored bar) with tissue labels further classified into tissues (e.g., bone, blood), developmental (e.g., fetal, embryo), and organ (e.g., breast, kidney). The ON-DOWN TFs (at the top, blue) tend to be shared across samples. The ON-UP (red) shows a variety of patterns including tissue specific pockets (middle) and ubiquitously on and active (bottom)

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Genome Biology

ISSN: 1474-760X

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