Fig. 8

The high activation of ASPM-FOXM1 double positive feedback loop is a risk of poor prognosis for HCC patients. A Overall survival and disease-free survival rate of 31 solid tumors (including ACC, BLCA, BRCA, CESC, CHOL, COAD, ESCA, GBM, HNSC, KICH, KIRC, KIRP, LGG, LIHC, LUAD, LUSC, MESO, OV, PAAD, PCPG, PRAD, READ, SARC, SKCM, STAD, TGCT, THCA, THYM, UCEC, UCS, and UVM) from TCGA database were analyzed using the GEPIA platform; n = 9494. B Overall survival and disease-free survival rate of LIHC from TCGA database were analyzed using the GEPIA platform; n = 364. C Overall survival rate of LIHC from the TCGA dataset was analyzed according to the mRNA levels of ASPM and FOXM1. ASPM High / FOXM1 High (n = 133); ASPM High /FOXM1 Low (n = 21); ASPM Low /FOXM1 High (n = 22); ASPM Low /FOXM1 Low (n =118). D The mRNA levels of ASPM and FOXM1 in different stages of HCC. The significance was analyzed by one-way ANOVA. ns, no significance; **p < 0.01; ***p < 0.001. E A working model of this study