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Table 1 Study characteristics

From: Multi-ancestry whole genome sequencing analysis of lean body mass

Study

Discovery

Replication

Amish

CHS

FHS

SAFOS

WHI

LOS

UKBB (WGS)

UKBB (SNP-Chip)

N

484 (478)

1054

2863

409 (361)

934

4982

1115

4720

Female (%)

0.523

0.59

0.592

0.619

1

0.502

0.529

0.522

Age#

55.2 (14.9)

76.4 (4.7)

56.7 (13.0)

41.1 (15.7)

66.4 (6.8)

39.2 (11.2)

55.7 (7.6)

55.73 (7.6)

Height#

165.0 (8.9)

164.3 (9.4)

166.9 (9.6)

162.1 (9.1)

161.3 (6.0)

169.8 (9.2)

169.2 (9.2)

169.4 (9.2)

Weight#

75.1 (14.1)

72.9 (13.9)

75.6 (16.2)

78.8 (18.5)

74.1 (15.6)

79.8 (20.1)

77.1 (15.7)

77.3 (15.2)

Total fat#

21.8 (9.5)

26.9 (9.8)

26.7 (9.9)

30.9 (12.7)

32.8 (11.4)

24.8 (12.2)

25.9 (9.8)

26.0 (9.4)

WB-LM#

50.8 (10.5)

44.4 (10.1)

45.5 (11.2)

47.8 (11.8)

38.0 (5.6)

55.0 (12.3)

47.2 (10.0)

47.3 (9.8)

A-LM#

22.4 (5.7)

18.1 (5.0)

19.9 (5.7)

19.2 (6.0)

14.9 (2.9)

24.7 (6.3)

21.3 (5.3)

(5.2)

  1. N: sample size of WB-LM (sample size of A-LM)
  2. #: mean (standard deviation); results are based on the larger sample size which is WB-LM
  3. Age is in years, height is in cm, and weight, total fat, WB-LM, and A-LM are in kg
  4. Amish: Amish Cohort; CHS: Cardiovascular Health Study; FHS: Framingham Heart Study; SAFOS: San Antonio Family Osteoporosis Study; WHI: Women’s Health Initiative; LOS: Louisiana Osteoporosis Study; UKBB (WGS): UK Biobank for WGS samples; UKBB (SNP-Chip): UK Biobank for imputed genotype samples