Fig. 3
From: Admixture as a source for HLA variation in Neolithic European farming communities
Enrichment of western hunter-gatherer (WHG) ancestry in the MHC region of late farmers (LF). A Local estimates of WHG ancestry in the MHC region (highlighted in green; chr6:28,477,797–33,448,354) of LF, along with the 5-Mb flanking regions on either side. The Y-axis shows the average probability of WHG ancestry for each variant in high-coverage LF individuals (n = 19) used in the local ancestry analysis. The grey dashed line represents the mean genome-wide WHG ancestry. B Comparison of the mean WHG ancestry across the MHC region between carriers (green) and non-carriers (orange) of alleles A*02:01, DRB1*08:01, and DQB1*04:02. The Y-axis represents the mean WHG ancestry probability of variants in the MHC region per individual. Significance of the difference in mean WHG ancestry between carriers and non-carriers of each allele was assessed using the Mann–Whitney test, with multiple testing correction applied (*: p ≤ 0.05; ns: not significant)