Fig. 5
From: Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci
Gene regulatory mechanisms underlying the rs13401811 locus. A Chromatin accessibility of peak chr2:110,858,286 vs the genotype of rs13401811. B Loop strength of the loop connecting the enhancer with the promoter of BCL2L11 vs the peak height of the enhancer. C Visualization of the region surrounding rs13401811. Top: ATAC-seq peaks. The intensity of the color indicates the average peak height of the peak, whilst position across the Y-axis indicates Pearson’s correlation with the peak height of the enhancer chr2:110,858,286. Middle: Genes from Gencode v29. The red dots indicate the transcription start sites. Bottom left: Correlation between the Hi-C contacts and the peak height of the enhancer chr2:110,858,286. Bottom right: Merged Hi-C map. The green box indicates the loop that connects the enhancer with the promoter of BCL2L11