Fig. 3
From: Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci
Gene regulatory mechanisms underlying the rs12936231 locus. A Accessibility of the CTCF site located at chr17:39,872,642 vs the genotype of rs12936231. B Representative loopQTL with the genotype of rs12936231 in the region. Loop displayed is chr17:39,872,500–39977500. C Visualization of the region surrounding rs12936231. Top: ATAC-seq peaks. The intensity of the color indicates the average peak height of the peak, whilst position across the Y-axis indicates Pearson’s correlation with the genotype of rs12936231. Middle: Genes from Gencode v29. The red dots indicate the transcription start sites. Bottom left: Correlation between the Hi-C contacts and the genotype of rs12936231. Bottom right: Merged Hi-C map