Fig. 2
From: Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci
Chromatin conformation is linked to gene expression and genotype. A Visualization of the region surrounding IL7R. Top: ATAC-seq peaks. The intensity of the color indicates the average peak height of the peak, whilst position across the Y-axis indicates Pearson’s correlation with the expression of IL7R. Middle: Genes from Gencode v29. The red dots indicate the transcription start sites. Bottom left: Correlation between the Hi-C contacts and the expression of IL7R. Bottom right: Merged Hi-C map. B Venn diagram showcasing the overlap between chromatin accessibility allelic imbalance results from CD4+ T cells, CD8+ T cells, and merged dataset. C Venn diagram showcasing the overlap between loop allelic imbalance results from CD4+ T cells and CD8+ T cells. D Accessibility of the CTCF site located at chr11:95,578,036 vs the genotype of rs4409785. E Visualization of the region surrounding rs4409785. Top: ATAC-seq peaks. The intensity of the color indicates the average peak height of the peak, whilst position across the Y-axis indicates Pearson’s correlation with the genotype of rs4409785. Middle: Genes from Gencode v29. The red dots indicate the transcription start sites. Bottom left: Correlation between the Hi-C contacts and the genotype of rs4409785. Bottom right: Merged Hi-C map