Table 1 Comparison of MoCHI capabilities to previously developed methods
Feature | LANTERN [20] | MAVE-NN [7] | MoCHI |
|---|---|---|---|
Global (non-specific) epistasis inference | Yes | Yes | Yes |
User-specified mechanistic model fitting | No | Yes | Yes |
Pairwise genetic interaction inference (specific epistasis) | No | Yes | Yes |
Multidimensional global (non-specific) epistasis inference | Yes | No | Yes |
Model fitting to multiple (multimodal) phenotypes | Yes | No | Yes |
Simultaneous fitting of global (non-specific) and pairwise (specific) epistasis | No | Yes | Yes |
Higher-order genetic interaction inference | No | No | Yes |
Ensemble (background-averaged) epistasis inference | No | Yes | Yes |
Sparse epistatic model fitting | No | No | Yes |