Fig. 7
From: VI-VS: calibrated identification of feature dependencies in single-cell multiomics
ST T cells experiment. A Tissue segmentation into lymph nodes and tumor regions. B Identified spatial DE genes by VI-VS in T cells, along with spatial LFCs (positive values denote gene upregulation in lymph nodes compared to tumors) against the significance scores of VI-VS. C Local density of tumor cells in the tissue. Density is estimated using kernel density estimation (bandwidth of 500 µm). D Identified T cell genes conditionally associated with local density of tumor cells, along with marginal Spearman scores between gene expression and local tumor density