Fig. 4

A Examples of gene groups identified by VI-VS in the semi-synthetic experiment. Clusters 1 and 2 show examples where all genes affecting the surface protein expression in the simulation are detected at the gene level. Clusters 3 and 4 show examples where some of the genes are not detected at the gene level but are detected at coarser resolutions. Clusters 5 and 6 show examples where none of the genes are detected at the gene level but are detected at coarser resolutions. B FDR (left) and power (right) for VI-VS applied at different resolutions. When testing at the group level, a group of genes was considered a true positive if it contained at least one gene that was a true positive at the gene level