Fig. 8

The K36MTs have distinct genomic preferences in the deposition of H3K36me. a SETD2 couples to the phosphorylated RNAPII complex (RNA Pol II) and deposits H3K36me3 at exons with higher enrichment in 3′ regions where exon density becomes higher. This takes place at the expense of H3K36me2, which display the opposite 5′ to 3′ and exon/intron trends. b NSD1 is recruited to active CpG islands and then spreads outwards into both gene bodies and intergenic regions, depositing broad H3K36me2 domains. c NSD2 may have a specific affinity for depositing H3K36me2 within genes, while also depositing broad intergenic H3K36me2 domains. d NSD3 spreads outwards from CpG-rich regulatory elements and deposits narrower H3K36me2 peaks. e ASH1L primarily deposits H3K36me2 at the promoters and enhancers of specific genes. Created with BioRender.com