Fig. 4
From: Characterization of regeneration initiating cells during Xenopus laevis tail regeneration
Trajectory, regulon and cell–cell communication pathway analysis associated with RICs. A CellRank analysis showing the UMAP projections of the clustered locations for the selected cell states. "Basal epidermal (tp63 +) 1" represents the initiating population. UMAP showing the cells that are identified as terminal states and the fate probability of each cell towards a given cell state. B Gene regulatory network of the RIC’s specific transcription factors that are differentially (fold change > 2x, Padj < 0.05) expressed. Shown are examples of the correlated associated regulons. Heatmap is based on z-score of the AUC (area under the curve) scores for each cell. Columns are ordered by cell type. C Cell–cell communication network comparison between 1 and 3 hpa showing the major sources and targets for the signals, all signal changes associated with the RICs, and the differential pathways involving RICs