Skip to main content

Table 1 List of CRISPR targets with multiple paralogs demonstrating large increases in paralog expression. All CRISPR targets with more than 1 paralog in the top-100 list (see the “Methods” section) and with at least 10% of all annotated paralogs in the top-100 lists. A complete list of CRISPR targets with paralogs in the top-100 list is in Additional File 1: Table S3

From: Prevalence of and gene regulatory constraints on transcriptional adaptation in single cells

CRISPR target

# paralogs in top-100

# annotated paralogs

Fraction of paralogs in top-100

TMED10

5

9

0.56

ILF2

5

13

0.39

CDK6

8

26

0.31

PABPC1

6

21

0.29

NONO

2

7

0.29

SMAD4

2

7

0.29

IRF4

2

8

0.25

FRZB

3

14

0.21

EIF4A1

7

36

0.19

PPIA

3

16

0.19

RAB27A

11

66

0.17

DDX39A

6

36

0.17

DDX17

5

36

0.14

CCND1

2

17

0.19

HLA-C

2

17

0.19

HLA-F

2

17

0.19

SERPINE2

3

27

0.11

FKBP4

2

18

0.11