Fig. 5

Activation of genomic loci in a subset of CLL patients. a Strategy for mapping CMs using available ChIP-seq for H3K27ac in LCL (n = 317) and CLL (n = 105) samples. b Log2 ratio of interindividual variance of aCM activity (x-axis) and interindividual variance in expression of the gene(s) embedded within the CM. Colors represent whether the promoter of the gene is part of the CM. Correlation values are Pearson correlation. Boxplots represent the distribution of the interindividual variance. c Example depicting the OSBPL5 locus whose embedded gene’s expression is induced in a subset of CLL patients. d CM activity stratified by genotype of the candidate-associated variant rs895555. e Event-free survival of CLL patients stratified on OSBPL5 expression for both IGHV-mutated and -unmutated CLL status. p values were obtained using a log-rank test. p value indications are non-significant (ns) for p value > 0.05, * for 0.01 < p value ≤ 0.05, and ** for 0.001 < p value ≤ 0.01