Fig. 3
From: sciMET-cap: high-throughput single-cell methylation analysis with a reduced sequencing burden
Demonstration of sciMET-cap performance using a benchtop sequencer. a UMAP visualization and cell type clustering of a nearly 6000 cell sciMET-cap PBMC dataset. b Genome browser tracks of DNA methylation at marker genes. Top: Epigenome Blueprint bulk bisulfite sequencing data on sorted cell populations. Bottom: Aggregated cells within each cluster from sciMET-cap dataset. c Percent of individual CG sites covered by aggregate cell coverage for each cluster colored by cluster identity in a (left), for all CG sites on target (middle), and percent of 1500-bp windows used in DMR calling with a minimum coverage of 10 (right). d Cluster-specific DMRs with Genscript and Genehancer annotations