Fig. 3

Non-random mutational distribution in non-escaped tumors. dN/dS for A IDH1 and B KRAS in escape − (red) and escape + (blue) groups including number of nonsynonymous (upper number) and synonymous (lower number) mutations. Lolliplots for mutations in escape − and escape + tumors for C IDH1 and D KRAS. Chi-square test comparing mutation number and unique mutated sites for E IDH1 and F KRAS. G Chi-2 p-value for significant known driver genes comparing the number of mutations versus the number of sites in both groups