Fig. 2

Selective landscape in escape + and escape − tumors. A Overall driver dN/dS for escape + and escape − tumors across all TCGA tumor types. B Overall driver dN/dS for 31 cancer subtypes separated by escape status (red—escaped − , blue—escaped +). Volcano plot for gene-level dN/dS using missense mutations versus p-value (Log10). Venn diagram showing the number of significant driver genes (Q-value < 0.1) using missense mutations considering E all genes or F restricted to known driver genes when separating by escape group or with all samples together. G List of significant driver genes using missense mutations in at least one group. H dN/dS value for significant genes in escaped − versus escaped + groups