Fig. 8
From: Disruption of maternal vascular remodeling by a fetal endoretrovirus-derived gene in preeclampsia
PEG10 overexpression negatively impacts endothelial cell proliferation and function. a Optical density in MTT assay of PEG10 in HUVEC cells transfected with control vector (OE-control) or PEG10-overexpression (PEG10-OE-1, PEG10-OE-2) vectors (left), or HUVEC cells transfected with control scrambled siRNA (siRNA control) or PEG10-targeting siRNA (PEG10-siRNA-1, PEG10-siRNA-2) (right). P-values were examined by t-test and adjusted with “BH” method. b Cell cycle-related gene expression score (S and G2/M) in PEG10 RNAi, control, and PEG10 overexpression (OE) cells by single-cell RNA sequencing. c Junction count in tube formation assay for HUVEC cells transfected with control or PEG10-overexpression vectors. d Tube count in tube formation assay for HUVEC cells transfected with control or PEG10-overexpression vectors. e Junction count in tube formation assay for HUVEC cells transfected with control or PEG10-targeting siRNA. f Tube count in tube formation assay for HUVEC cells transfected with control or PEG10-targeting siRNA. P-values were examined by t-test, not adjusted