Fig. 6
From: Saturation-scale functional evidence supports clinical variant interpretation in Lynch syndrome
Mutational patterns in patients with somatic MSH2 missense variants. Tumor and germline mutations in LS genes are shown in patients who carry functionally neutral somatic MSH2 missense variants (upper track, n=38), or those with a functionally abnormal somatic MSH2 variant (lower track, n=46). Mutations and tumor characteristics are denoted as in Fig. 5A