Fig. 6
From: Reprogramming of RNA silencing triggered by cucumber mosaic virus infection in Arabidopsis
Proposed model. CMV infection leads to the accumulation of its genomic RNAs which are recognized by the RNA silencing machinery producing 21- (mainly) and 22-nt vsiRNAs. These vsiRNAs are then incorporated into the endogenous antiviral machinery mediated by AGO2, AGO1, AGO5, and AGO7 and inhibited by the 2b protein. As a side effect of this antiviral activity, vsiRNAs are also incorporated into the endogenous RNA silencing pathways mediating the silencing of endogenous genes. Together with this, 2b binds to endogenous mRNA-derived sRNAs and is involved in the transcriptional regulation of these genes