Fig. 5

Evolution of CR binding sites from RSINE1 is context-dependent. A Distribution of distance from each CR-bound (n = 328) or all (n = 115,806) RSINE1 elements to the nearest non-repetitive CR binding site (Non-RABS). Boxplots show the median (center line), the 1st and 3rd quartiles (hinges), and 1.5 × IQR (whiskers). Statistical testing was done using the Mann-Whitney/Wilcoxon rank sum test. Distances on the schematized drawing represent the median distance in each class. B Fraction of Non-RABS and RABS CR binding sites that can be traced to the human or rat genomes using liftOver. C Fraction of CR-bound and unbound RSINE1 elements that can be traced to the human or rat genomes using liftOver. D Fold change CACGTG motifs detected in bound RSINE1 elements compared to unbound OC RSINE1 elements in the mouse as well as in syntenic orthologs in the rat